Storm Reid

Meg Murry

Oprah Winfrey

Mrs. Which

Reese Witherspoon

Mrs. Whatsit

Mindy Kaling

Mrs. Who

Levi Miller

Calvin O'Keefe

Deric McCabe

Charles Wallace Murry

Chris Pine

Dr. Alex Murry

Gugu Mbatha-Raw

Dr. Kate Murry

Zach Galifianakis

The Happy Medium

Rowan Blanchard

Veronica Kiley

Michael Peña

Red

André Holland

Principal Jenkins

Bellamy Young

Camazotz Woman

David Oyelowo

The It (voice)

Conrad Roberts

Elegant Man

Lyric Wilson

Young Meg

Yvette Cason

Mrs. Teacher

Will McCormack

Mr. Teacher

Daniel MacPherson

Calvin's Father

Akemi Look

Air Force Officer

Tim Kang

School Superintendent

Michele Norris

Radio News Broadcaster (voice)

Claire Montwill

Student

Catelynn Brown

Meg Double

Ariyah Brown

Meg Double

Losa Fifita

Meg Double

Joyce Larkin

Mrs. Who Double

Teonee Motley

Mrs. Which Double

Jessica Rockwell

Mrs. Whatsit Double

Oz Kalvan

Charles Wallace Double

Isaac Ordonez

Charles Wallace Double

Kai Miller

Charles Wallace Double

Leighton Leevard

Charles Wallace Double

Guillaume Seeleuthner

Charles Wallace Double

Jacob Eddington

Charles Wallace Double

Easton Tath

Baby Charles Wallace

Giselle Paredes

Baby Charles Wallace

Punnavith Koy