Johnny Depp

Donnie Brasco / Joseph D. 'Joe' Pistone

Al Pacino

Benjamin 'Lefty' Ruggiero

Michael Madsen

Dominick 'Sonny Black' Napolitano

Bruno Kirby

Nicholas 'Nicky' Santora

James Russo

Paulie

Anne Heche

Maggie Pistone

Zeljko Ivanek

Tim Curley

Brian Tarantina

Bruno

Rocco Sisto

Richard 'Richie' Gazzo

Zach Grenier

Dr. Berger

Gerry Becker

Agent Dean Blandford FBI

Robert Miano

Alphonse 'Sonny Red' Indelicato

Paul Giamatti

FBI Technician

Gretchen Mol

Sonny's Girlfriend

Tim Blake Nelson

FBI Technician

Walt MacPherson

Sheriff

Ronnie Farer

Annette

Terry Serpico

Strip Club Owner

Tony Lip

Philip 'Philly Lucky' Giaccone

George Angelica

Big Trin

Val Avery

Santo Trafficante Jr.

Madison Arnold

Jilly

Delanie Fitzpatrick

Daughter

Katie Sagona

Daughter

Sara Gold

Daughter

Larry Romano

Tommy

James McCauley

FBI Agent

James Bulleit

U.S. Attorney

Andrew Parks

Hollman

Keenan Shimizu

Japanese Maitre D'

Rocco Musacchia

Trafficante's Man

Joe Francis

Trafficante's Man

Sal Jenco

Mare Chiaro Bartender

Billy Capucilli

Communion Party Man

Laura Cahill

Communion Party Woman

Doreen Murphy

Mob Girlfriend

Denise Faye

Mob Girlfriend

Elaine del Valle

Mob Girlfriend

John Horton

FBI Director

Dan Brennan

FBI Photographer

LaJuan Carter

Singer

Sandy Barber

Singer

Joyce Stovall

Singer

Frank Pesce

Wiseguy

Randy Jurgensen

Wiseguy

John Di Benedetto

Wiseguy

Richard Zavaglia

Wiseguy

Tony Ray Rossi

Wiseguy

Edward Black

Wiseguy

Gaetano LoGiudice

Wiseguy

Carmelo Musacchia

Wiseguy

Pat Vecchio

Wiseguy

Caleb

The Lion

Flint Beverage

Kings Court Cop (uncredited)

Frank Bonsangue

Sonny Red's Crew (uncredited)

Mark Todd Bruner

FBI Agent (uncredited)

Teresa Giudice

Shocked Stripper (uncredited)

Barry Hirschberg

Background (uncredited)

Jim Lavin

Arresting FBI Officer (uncredited)

Peter O'Hara

Passerby (uncredited)

Antone Pagán

Prison Guard for Pacino and Depp (uncredited)

Garry Pastore

Carmine Galante's Bodyguard

Dale Resteghini

Strip Club Patron (uncredited)

Larry Tobias

Man in Bar (uncredited)

Elle Alexander

Mob Girlfriend

Frankie Cee

Civilian (uncredited)

Craig "Radioman" Castaldo